are the benefits of SAM-e?
SAM-e is substance naturally found in all body tissues. The body needs it in
chemical reactions for making complex substances such as proteins,
hormones, neurotransmitters and enzymes. Having enough SAM-e in the body
ensures that these essential chemical reactions work at full speed.
levels of SAM-e may cause many of these life-essential chemical
processes to slow down leading to a variety of health problems such as
depression and osteoarthritis.
The body can make SAM-e and the body has the highest concentration when
you are young. The levels decline as you age.
Evidence of the
Benefits of SAM-e
Benefits of SAM-e and Traditional Uses
Chronic fatigue syndrome (CFS)
Enhance mental performance
Lower back pain
Multiple sclerosis (MS)
Muscle / Skeletal (bursitis and tendonitis)
Premenstrual syndrome (PMS)
on Selected Research Studies on SAM-e
name for SAM-e is S-adenosy-L-methionine. It's not a surprise everyone
calls it SAM-e. It is a methyl donor, allowing simple molecules to
join together to form complex molecules. This process is absolutely
essential to life.
SAMe is known
to increase the levels of dopamine (a neurotransmitter) found in the
brain. This helps to regulate mood. Several double-blinded clinical
trials show that SAM-e is effective for treating depression.
advantage of SAM-e over other herbal antidepressants such as St. John's
is that it can work quite fast. Indeed some subjects
significant improvements in about 7 days.
The liver is
not able to produce
SAM-e in liver disease. SAM-e is used to make one of the body's
essential antioxidant glutathione, needed to protect the liver and the
body against oxidative damage.
Clinical studies show that
taking SAM-e improves liver function in people suffering from alcohol
liver cirrhosis and choleostasis.
SAM-e seems to
reduce pain and prevent inflammation. Other studies suggest that it can
protect the joint from further damage.
Several clinical studies show that SAM-e is as effective as prescription
anti-inflammatory drugs such as Celebrex (celecoxib), Aleve (naproxen)
and Advil (ibuprofen) for treating
arthritis pain. Moreover, the volunteers reported much less side
effects compared to the prescription pain killers.
In one study,
volunteers taking SAM-e reported significant reduction in fatigue, pain,
mood and stiffness.
Some earlier studies
seem to show that taking SAM-e can improve sperm speed in men who suffer
Deficit-Hyperactivity Disorder (ADHD) in Adults
involving adults suffering from ADHD seems to show some benefits of
taking SAM-e. Since the subjects knew what they were taking, there may
be a placebo
at work here.
SAMe Side Effects
effects are not common. People taking SAM-e for over 2 years in clinical
studies only reported minor stomach upset.
There are several reported cases of SAM-e causing a person suffering
from bipolar disorder to swing from depression to the manic stage.
Experts suggest not taking SAM-e in those with bipolar disorder.
Below are dosages of
SAM-e that have been used in clinical studies. Start with the lower dose
and increase gradually until you see the results. Divide the daily
recommended dose to two or three times daily.
- Take 600 to 1,200 mg daily
- Take 600 to 1,200 mg daily.
- 1,600 mg daily.
400 mg twice daily.
- 800 mg daily.
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