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Benefits of SAM-e

What are the benefits of SAM-e?

SAM-e is substance naturally found in all body tissues. The body needs it in chemical reactions for making complex substances such as proteins, hormones, neurotransmitters and enzymes. Having enough SAM-e in the body ensures that these essential chemical reactions work at full speed.

Low levels of SAM-e may cause many of these life-essential chemical processes to slow down leading to a variety of health problems such as depression and osteoarthritis.

The body can make SAM-e and the body has the highest concentration when you are young. The levels decline as you age. 

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Evidence of the Benefits of SAM-e

Leaf Natural Remedies Herbal Review Benefits Side Effects
Osteoarthritis
Leaf Natural Remedies Herbal Review Benefits Side Effects Liver Disease (Cirrhosis)
Leaf Natural Remedies Herbal Review Benefits Side Effects Depression
Leaf Natural Remedies Herbal Review Benefits Side Effects Fibromyalgia
Leaf Natural Remedies Herbal Review Benefits Side Effects Liver Disease (Cholestasis)
Leaf Natural Remedies Herbal Review Benefits Side EffectsMigraine Headaches
Leaf Natural Remedies Herbal Review Benefits Side Effects Generalized Anxiety Disorders
Leaf Natural Remedies Herbal Review Benefits Side Effects Attention Deficit-Hyperactivity Disorder (ADHD) in Adults
Leaf Natural Remedies Herbal Review Benefits Side Effects Bipolar Disorder
Leaf Natural Remedies Herbal Review Benefits Side Effects Infertility


Other Suggested Benefits of SAM-e and Traditional Uses

Alzheimer's disease
Anxiety
Anti-aging
Chronic fatigue syndrome (CFS)
Dementia
Enhance mental performance
Heart disease
Lower back pain
Migraine
Multiple sclerosis (MS)
Muscle / Skeletal (bursitis and tendonitis)
Premenstrual syndrome (PMS)
Parkinson's disease
Seizure


Information on Selected Research Studies on SAM-e

The scientific name for SAM-e is S-adenosy-L-methionine. It's not a surprise everyone calls it SAM-e. It is a methyl donor, allowing simple molecules to join together to form complex molecules. This process is absolutely essential to life.

Depression

SAMe is known to increase the levels of dopamine (a neurotransmitter) found in the brain. This helps to regulate mood. Several double-blinded clinical trials show that SAM-e is effective for treating depression.

The advantage of SAM-e over other herbal antidepressants such as St. John's wort is that it can work quite fast. Indeed some subjects reported significant improvements in about 7 days.

Liver Diseases

The liver is not able to produce SAM-e in liver disease. SAM-e is used to make one of the body's essential antioxidant glutathione, needed to protect the liver and the body against oxidative damage.

Clinical studies show that taking SAM-e improves liver function in people suffering from alcohol liver cirrhosis and choleostasis.

Osteoarthritis

SAM-e seems to reduce pain and prevent inflammation. Other studies suggest that it can protect the joint from further damage.

Several clinical studies show that SAM-e is as effective as prescription anti-inflammatory drugs such as Celebrex (celecoxib), Aleve (naproxen) and Advil (ibuprofen) for treating arthritis pain. Moreover, the volunteers reported much less side effects compared to the prescription pain killers.

Fibromyalgia

In one study, volunteers taking SAM-e reported significant reduction in fatigue, pain, mood and stiffness.

Infertility in Men

Some earlier studies seem to show that taking SAM-e can improve sperm speed in men who suffer from infertility.

Attention Deficit-Hyperactivity Disorder (ADHD) in Adults

One study involving adults suffering from ADHD seems to show some benefits of taking SAM-e. Since the subjects knew what they were taking, there may be a placebo effect at work here.


SAMe Side Effects

SAM-e side effects are not common. People taking SAM-e for over 2 years in clinical studies only reported minor stomach upset.

There are several reported cases of SAM-e causing a person suffering from bipolar disorder to swing from depression to the manic stage. Experts suggest not taking SAM-e in those with bipolar disorder.


SAM-e Dosage Recommendations

Below are dosages of SAM-e that have been used in clinical studies. Start with the lower dose and increase gradually until you see the results. Divide the daily recommended dose to two or three times daily.

Osteoarthritis - Take 600 to 1,200 mg daily

Liver Disease - Take 600 to 1,200 mg daily.

Depression - 1,600 mg daily.

Fibromyalgia - 400 mg twice daily.

Migraine - 800 mg daily.

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Related Articles and Resources for Benefits of SAM-e

Natural Cures for Anxiety Disorders

Natural Remedies for Osteoarthritis

Natural Remedies for Fibromyalgia



 
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Selected References for Benefits of SAM-e
Revised: February 26, 2011
 

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