CoQ10 Dose - Recommendations from Pharmacists

Coenzyme Q10 (ubiquinone) has been hailed as the ultimate anti-aging and heart healthy supplement by many experts.

Hype? Perhaps.

Studies have shown benefits for a wide variety of health problems including treating heart disease and high blood pressure.

If you would like to find out all the Health Benefits of this supplement, see the Full Review on Coenzyme Q10.

In this article, our main focus is to make recommendations on the most appropriate dose of CoQ10 to take for various health concerns based on available clinical studies.

Recommendations on Coenzyme Q10 Dose from Scientific Studies

The CoQ10 dose recommendations below are based on the dosage used in published clinical trials. They range from a low of 50 mg to a high of 1,200 my daily.

The higher CoQ10 dosage will need to be divided into two or three times daily. (For example, if you are taking 300 mg daily, we suggest taking 150 mg twice daily or 100 mg three times daily.)

If you are taking it for general heart health, a dose of 100 mg once daily is a suitable starting dose.

Deficiency in Coenzyme Q10

The dose used to treat CoQ10 deficiencies varies greatly depending on the severity of the deficiency.

Generally experts recommend starting at 2 mg/kg/day. (Example, if you weigh 50 kg or 110 pounds, you'll be taking 100 mg per day.) Dose as high as 3,000 mg daily have been used.

High Blood Pressure

For lowering high blood pressure, 60 to 100 mg twice daily have been used in clinical studies.

The article CoQ10 for Blood Pressure discuss this use specifically.

See Natural Remedies for High Blood Pressure for a discussion on herbs and supplements to reduce blood pressure.

Heart Failure (Congestive Heart Failure)

The dose used is 100 mg daily. Even a low dose of 60 mg per day showed benefits in one research study. In some clinical trials, dose as high as 900 mg daily have been given to those suffering from advanced congestive heart failure.

See CoQ10 for Heart Failure for this particular discussion and clinical studies.

Heart Attack (Myocardial Infarction or MI)

Individuals who suffered a heart attack are more likely to experience another one. CoQ10 has been prescribed by some experts to reduce the risk of a second heart attack.

See Natural Remedies for Heart Attack for complete information on natural solutions for this health condition.

Dose used is 60 mg twice daily.

Angina (Angina Pectoris)

Experts have suggested using 50 mg three times daily to treat angina pectoris.

Chronic Fatigue Syndrome (CFS)

Experts have suggested taking at least 200 mg daily. Dosages up to 600 mg daily have be proposed for those suffering from severe chronic fatigue syndrome.

Migraine Headaches

Research studies have typically used 100 mg three times daily.

See Migraine Cures for a complete set of articles on treating migraine headaches with natural remedies.

High Cholesterol

Taking 100 mg of CoQ10 seemed to increase the "good cholesterol" (HDL) but it did not appear to have any effects on the "bad cholesterol" (LDL) levels.

The article Natural Remedies for High Cholesterol provides more specific information about natural treatments that can be used.

Gum Disease (Gingivitis)

For treating gum disease, studies have used 85 mg of CoQ10 suspended in soybean oil placed on the affected gum tissue once a week.

Another study showed that even a low dose of 50 mg daily helped to reduce inflammation caused by gingivitis.

See Coenzyme Q10 for Gum Disease for this particular use.

Cancer Treatment

Studies have used 100 mg daily of coenzyme Q10 in combination with other antioxidants such as vitamin C, selenium, folic acid and beta-carotene for cancer treatment.

There are no clinical studies that looked at just using CoQ10 by itself for cancer treatment or prevention.

So it would be difficult to tell if it is just the CoQ10 that worked or the combination or even if it is the other supplements included in the study.

This is not the ideal situation with regards to the design of the research study. We will not truly know if CoQ10 really works against cancer by itself.

Dose as high as 390 mg has been used with conventional cancer treatment protocol.

The articles CoQ10 for Cancer and CoQ10 for Breast Cancer talk about the research studies focused on using the supplement for cancer prevention and treatment.

See Natural Remedies for Cancer for a complete list of supplements that are recommended by experts.

Boost Athletic Performance

Studies have used 200 mg daily for increasing muscle strength and performance.

Dementia and Alzheimer's Disease

Dosage of 300 mg twice daily have been used in an attempt to slow down Huntington's disease (nerve degeneration leading to loss of muscle control and dementia).

See Natural Remedies for Dementia for more information on natural remedies for treating this debilitating health condition.

Muscular Dystrophy

Studies have used 100 mg daily.

Parkinson's Disease

Experts have used dose ranging from 300 mg to 1,200 mg daily (divided into four times daily) to reduce the symptoms of Parkinson's Disease.


Studies looking to see if CoQ10 helped with HIV/AIDS patients used 200 mg daily.


One study used 200 mg of coenzyme Q10 combined with 200 mg of Ginkgo biloba.

See CoQ10 for Fibromyalgia for information on this particular use.

Diabetes (High Blood Sugar Levels)

CoQ10 Dose of 100 mg once to twice daily were used to treat diabetes and reduce complications from diabetes.

See Natural Remedies for Type 2 Diabetes for more information on treating type 2 diabetes with natural remedies and supplements.

Increase Sperm Count (Male Infertility)

CoQ10 dose used to boost male fertility is 200 mg daily taken for a period of 6 months.

See Herbs to Increase Fertility to discover how to increase sperm motility and enhance fertility in both men and women.

What Else Should I Be Aware of?

CoQ10 dosage (up to 1,200 mg daily) is very well tolerated and most users would not experience any significant side effects.

Indeed, research studies show that most side effects happen in less than 1 out of 100 people who take CoQ10 supplements.

See Side Effects of CoQ10 for a discussion on some of the possible side effects that might occur when using this supplement.

Bottom Line

For most people who are looking to take coenzyme Q10 for general health, a dose of 100 mg daily should be sufficient and it represents a good starting dose.

Those who have a heart condition can take 100 mg twice daily (or 200 mg once daily).

Dosages higher than 300 mg daily are taken for other health conditions and consultation with a health care professional is recommended.

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Revised: December 15, 2016