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Ginseng
(Panax Ginseng)


open quote logo quotation The Chinese have known for thousands of years about the power of ginseng in helping one cope with everyday stress. It benefits the body in many ways including boosting the immune system and slowing down aging. close quote quotation logo




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In Chinese history, the herb, with its resemblance to a human body, is believed to cure many human diseases. The Chinese consider this to be the ultimate herb, one that can used to bring youth, strength, vitality, longevity and wisdom.

When buying ginseng, be aware of the type of ginseng that it contains.
Marketed as an aphrodisiac and for treating erectile dysfunction, many products contain multiple ingredients such as yohimbe (yohimbine), catuaba, horny goat weed (epimedium), maca, ginkgo, L-arginine, damiana, muira puama, tribulus terrestris and vitamins and minerals.

Marketed as a treatment or prevention of the common cold, a product called COLD-fX is specifically designed for this purpose.

Erectile Dysfunction (ED) and  Sexual Dysfunction - You may see benefit from taking this herb. Either use this herb by itself or in combination products. Use 200 mg to 1000 mg three times daily. Try it for about a month before deciding if it helps or not.

Adaptogen (increased resistance to stress) and well-being - This is the main use of this herb in the past. You may use this herb for this purpose especially if you are always tired and feel run-downed most of the time. Start with about 200 mg daily and increase to 1000 mg three times daily as needed.

Improving Memory in Patients with Alzheimer's Disease (AD) - It is worth trying this herb for those suffering from AD. Start by taking 1000 mg three times daily. Try it for at least 3 months before deciding to discontinue it because it did not seem to work. There are many stages of AD and ginseng may not work on all stages of the disease.

Preventing and Treating the Common Cold - As ginseng is an adaptogen and suspected to support the immune system, you can expect it to help prevent or shorten the period of the common cold. The product COLD-fX has clinical studies done to prove that it works to prevent and treat the common cold.


Table of Contents


Evidence of Benefits (Leaf rating system)

Leaf Natural Remedies Herbal Review Benefits Side Effects Erectile Dysfunction (ED) / Impotence

In Asia, this supplement is commonly included in herbal supplements used for treating sexual dysfunction. Recent studies in laboratory animals have shown that both Asian and American forms increase libido and sexual intercourse performance and frequency.

There is good evidence that ginsenosides can facilitate erection by increasing blood flow to the penis. Researchers believe that ginsenosides (the active ingredients) helps to increase nitric oxide production, a chemical in to body needed to cause an erection.

In one clinical study, the subjects taking this herb reported stronger erection (penile rigidity), libido and a higher sexual satisfaction than those taking the placebo.

Another well-designed clinical study in 60 men showed a significant improvement in the International Index of Erectile Function (IIEF-5), a standard used to measure the level of erectile dysfunction in men.

Click here for a list of other natural remedies that is used to treat ED.
 
Leaf Natural Remedies Herbal Review Benefits Side Effects Menopause Symptoms / Sexual Performance in Women (ArginMax and Phyto-Female Complex)

Research has been done on combination products such as ArginMax (containing L-arginine, ginseng, ginkgo, damiana, multivitamins, and minerals).

The results showed significant benefit in levels of sexual desire, satisfaction with overall sex life, frequency of sexual desire, frequency of intercourse, satisfaction with sexual relationship and vaginal dryness.

However, combination products such as Phyto-Female Complex (containing black cohosh, dong quai, milk thistle, red clover, American ginseng, chaste-tree berry) showed significant benefit in treating hot flushes and insomnia.

In combination products, it is very difficult to tell which of the multiple ingredients is responsible for the benefit seen.

Research does not support the use of a ginseng as the sole ingredient to treat menopause symptoms or sexual performance problems due to menopause.
 
Leaf Natural Remedies Herbal Review Benefits Side Effects Improving Memory in Patients with Alzheimer's Disease

Recent experimental evidences suggest protective effects of this herb in the memory function and mental performance of patients with Alzheimer disease (AD).

The study showed, surprisingly, that it is as effective as a prescription drug for treating AD. Some studies show that the herb helps with memory in those with Alzheimer's disease (AD).

It appears that ginseng has greater benefit in those with AD than those with normal memory function of health adults. The supplement was also shown to reduce the accumulation of the Alzheimer's amyloid beta peptide in the brains of animals.

Not all studies show positive result. One study showed that it does not provide any beneficial effects on memory performance in the long-term in healthy adult (Persson, 2004). Overall, there are more well-designed studies that show the benefit of using this herb on improving memory.
 
Leaf Natural Remedies Herbal Review Benefits Side Effects Common Cold / Influenza (Flu)

There are some clinical studies to show that this herb may be helpful in boosting the immune system, treating and shortening the duration of the common cold.

Note: Recently, there over ten clinical studies done on a proprietary extract of North American ginseng (COLD-FX). These studies showed that COLD-FX can significantly reduce the risk and duration of the cold by about 50%.
 
Leaf Natural Remedies Herbal Review Benefits Side Effects Diabetes (Non-Insulin Dependent / Type 2), Glucose Intolerance & Insulin Resistance

In many research studies, this herb showed the ability to reduce the standard 75 gram oral glucose tolerance test (OGTT) by 10% and increase the insulin sensitivity index by 33%.

One study showed that the herb improved the microcirculation and reduced urinary albumin (kidney leaking out protein) in diabetic patients with early stage kidney disease.

Another clinical study, the herb was also shown to reduce blood sugar levels after a meal in human subjects that did not have diabetes. However, this only worked if ginseng is taken 40 minutes before the meal.
 
Leaf Natural Remedies Herbal Review Benefits Side Effects Adaptogen (Resistance to Stress) / Well-Being / Quality of Life

The health benefits of this herb is recognized by many, especially those living in Asian countries.

A research study conducted in Mexico city showed that the supplement significantly improved quality of life such as energy, sleep, sexual satisfaction and general well-being.

One study showed that 200 mg daily of the herb, "elevated mood, improved psychophysical performance, and reduced fasting blood glucose (FBG) and body weight."

Another study showed that taking the supplement resulted in improved task performance throughout the day.

And in another study involving 332 individuals, the herb reduced fatigue.

Other smaller studies showed similar positive results.
 
Leaf Natural Remedies Herbal Review Benefits Side Effects Enhance Immune System / HIV Infection

There are several studies in animals that show that this herb can enhance the immune system. It is thought that this would help the body defend against bacterial and viral infections. These findings would suggest that it has adaptogen-like effects and can help fight off stress and create a sense of well-being.

In one study done in humans, long-term intake delayed the progression of human immunodeficiency virus (HIV-type 1) infected patients. The supplement also prevented the loss of immune cells (T cells) in the body. It also made the AIDS drug zidovudine work longer before the virus became resistant to it.

Another well-designed study showed that the extracts had positive effect in stimulating the immune cell production in healthy adults.
 
Leaf Natural Remedies Herbal Review Benefits Side Effects Enhance Sexual Performance / Increase Fertility

Animal studies show that this herb is able to increase sperm production, sexual performance and activity. A study conducted in 46 men showed that this herb increase sperm production and motility.
 
Leaf Natural Remedies Herbal Review Benefits Side Effects Alcohol Detoxification

A research study done in human subject showed that taking the extract reduced the blood alcohol levels by 35% to 51%.
 
Leaf Natural Remedies Herbal Review Benefits Side Effects Cancer Prevention

Note: The positive benefits (described below) of using this herb to prevent cancer is only shown in population studies, not in human clinical studies.

Smokers taking this supplement showed lower cancer risks for cancers of lung, lip, oral cavity and pharynx and liver than those without ginseng intake.

As well studies show that the risk for stomach and lung cancers was significantly reduced among those who take ginseng.

Studies in rats showed that taking this herb reduces the incidence of cancer.

Researchers believe that the ability of this herb to prevent cancer might be due to its ability to stimulate the immune system.
 
Leaf Natural Remedies Herbal Review Benefits Side Effects Premature Ejaculation

In a double-blinded, randomized, placebo controlled clinical study done in 50 human subjects with SS-cream, it significantly prolonged time to ejaculation by 10 minutes compared to the placebo cream. Subjects also reported an increase in sexual satisfaction.
 
Leaf Natural Remedies Herbal Review Benefits Side Effects Menopause Symptoms / Sexual Performance in Women

In one study the herb did not have any significant effect on the mood, anxiety levels, menopausal symptoms or sleepiness on post-menopausal women.

However, another study reported that using ginseng in postmenopausal women causes improvements in mood and anxiety."

The North American Menopause Society (NAMS, 2004) recommends first considering lifestyle changes, either alone or combined with a non-prescription remedy, such as dietary isoflavones, black cohosh, or vitamin E.
 
Leaf Natural Remedies Herbal Review Benefits Side Effects Weight Loss / Obesity

A recent study reviewed all the research data to see which herbs helps with weight loss. Ginseng (as well as ephedra, Cissus quadrangularis, bitter melon and zingiber) was found to be effective for bringing down weight. These studies included human and animal trials.
 
Leaf Natural Remedies Herbal Review Benefits Side Effects Aphrodisiac / Increase Libido (Sex Drive)

It has been shown that the saponins from ginseng can relax blood vessels and thus treat impotence but the aphrodisiac effect of ginseng may be an overstatement. More clinical studies are required before we can make any statement on the benefits of using this herb as an aphrodisiac.

Click here for other natural remedies that is used to increase sex drive.
 
Leaf Natural Remedies Herbal Review Benefits Side Effects Anti-inflammatory benefits

A new research study done in the lab setting shows that ginseng have anti-inflammatory benefits. While human studies are not currently available, it could help those suffering from inflammatory diseases such as arthritis, osteoarthritis and rheumatoid arthritis.
 
Enhance Athletic Performance - Not Likely Effective

Ginseng has been one of the most popular herbs said to improve human exercise performance. However, all the research studies we reviewed do not support this claim (Allen, 2008 / Engels, 1997 / Kulaputana, 2007 / Vogler, 1999 / Morris 1996).
 

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Facts about Ginseng

Ginseng is the root of the perennial herbs of Panax quinquefolium and Panax ginseng which contain a series of tetracyclic triterpenoid saponins (ginsenosides) as active ingredients.

Modern therapeutic claims refer to vitality, immune function, cancer, cardiovascular diseases, improvement of cognitive performance, age-related memory loss, physical performance and sexual function.

This herb comes in two forms, white and red. The description is used to distinguish the way they are processed.  White ginseng is harvested after four to six years and then dried in the air. Red ginseng is harvested after six years and steamed. Their colours come from their different processing methods.

It is considered a tonic or adaptogen that enhances physical performance (including sexual), promotes vitality and increases resistance to stress and aging. Ginseng (Panax, American and Siberian) are considered to be an adaptogen, chemical substances that can help the body cope with stress.

Ginseng is believed to reduce the recovery time from surgery and various disease conditions.

The main active components are ginsenosides, which have been shown to have a variety of beneficial effects, including anti-inflammatory, antioxidant, and anticancer effects.

Some initial studies suggest that the supplement can lower cholesterol and triglycerides in our body but it does not seem to have any direct benefit on cardiovascular health and heart disease. Studies also suggests that the supplement can lower blood sugar levels and promote insulin release. Some experts suggest it would be useful in treating people with non-insulin dependent diabetes (type 2) as it may reduce the need for prescription medications.

One interesting research study showed that the herb has antiviral activity. It seems to block the enzyme in the HIV needed to cover the virus genetic material (RNA) into a format (DNA) that could invade and infect our cells.

Because of its purported effects and apparently low rate of side effects, it remains one of the top selling natural product remedies in the United State.

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Suggested Benefits and Traditional Uses

Orally
  • adaptogen (increased resistance to stress) and well-being
  • alcohol intoxication (hangover)
  • anemia
  • anti-inflammatory benefits
  • anxiety
  • arthritis
  • aphrodisiac / enhance sex drive / increase libido
  • bacterial infection
  • cancer (breast, ovarian, liver, lung and skin)
  • chronic fatigue syndrome (CFS)
  • colitis
  • common cold
  • depression
  • diabetes
  • dizziness
  • enhance immune function
  • erectile dysfunction (ED) / impotence
  • fever
  • headaches
  • high blood pressure (hypertension)
  • high cholesterol
  • HIV infection
  • hot flashes (menopause symptom)
  • improving appetite
  • improving concentration
  • improving memory
  • increasing physical and athletic stamina
  • influenza (the flu)
  • insomnia
  • low sperm count / enhance male fertility
  • memory loss (Alzheimer's disease)
  • menopause symptoms
  • osteoarthritis
  • pregnancy disorder
  • rheumatoid arthritis
  • viral infection
  • weight loss

Topically (on the skin)
  • erectile dysfunction (ED) / impotence
  • premature ejaculation
  • skin wrinkle

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Side Effects, Toxicity and Warnings

In many research studies, human subjects using this herb reported very few side effects.

The most commonly reported side effect is insomnia. Other less common but possible side effects include high blood pressure, diarrhea, restlessness, mastalgia and one case of vaginal bleeding.

When used as a cream application on the penis, there may be a burning or stinging sensation. It may also desensitize the penis and thus delay ejaculation.

Safe - In appropriate doses, the herb is shown to be safe in many research studies.

Pregnancy and Lactation - There is limited studies. Avoid taking during pregnancy and breastfeeding when possible.

Children - Exercise caution if using in children as it might act as a stimulant.
     
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Common Drug & Health Condition Interactions

Warfarin / Blood Thinning Medications - caution

Research studies in human does not show this herb to affect blood clotting. However, studies done in laboratory settings shows it to reduce blood clotting.

Let your doctor monitor your PT or INR levels when starting or stopping this supplement. These would include Aspirin (ASA), Plavix (clopidogrel), Ticlid (ticlopidine) and others.

Diabetic Medications / Insulin - caution

This herb may lower blood sugar levels. Monitor your blood sugar levels more frequently when you are starting or stopping the herb. These would include Diabeta (glyburide), Glucophage (metformin), Actos (pioglitazone), Avandia (rosiglitazone), Amaryl (glimepiride), Diamicron (glicazlide), Humulin and Novolin insulins, and others.

Cyclosporine / Immune Suppressing Medications - theoretical

This herb is suspected to stimulate the immune system. Thus, in theory, it might counteract the effects of immune suppressing medications.

These would include Neoral or Sandimmune (cyclosporine), CellCept (mycophenolate), Prograf (tacrolimus), Deltasone (prednisone) and many others.

High Blood Pressure (Hypertension) - caution

This herb has been reported to increase blood pressure at a low dose but can decrease blood pressure at higher doses. Consult a healthcare professional and monitor your blood pressure when starting or stopping this supplement.

Autoimmune Disease - caution

This herb seems to stimulate the immune system. In people with an immune disorder such as multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriasis or ezcema (ectopic dermatitis), it may worsen the condition.

Use with caution under the guidance of a healthcare professional.
       
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Dosage & How to Take It

Available as capsules, tablets, fresh root (to make tea), dried root, tincture and extract. When possible, buy standardized extract so you know how much of the active ingredients (ginsenosides) will be contained in the pill.

Typical standardized extract of 200 mg of ginseng contains 4 to 5% ginsenosides.

Memory Loss / Alzheimer's Disease

Dosage of 4.5 grams daily for 12 weeks have been used.

Preventing Colds and Flu

Dosage of 100 mg and upwards taken daily have been used to prevent colds and flu. To get the maximum benefit, start taking the herb 1 week up to a 4 weeks before the beginning of the flu season.

Erectile Dysfunction (ED) / Impotence

Dosage of 1000 mg (1 gram) taken three times daily have been used.

Diabetes

Dosage of 200 mg once daily have been used to manage Type 2 diabetes (non-insulin dependent). In one study, the researcher concluded that 3 grams was the maximum; any higher dosage would not reduce blood sugar levels further.

Alcohol Intoxication

Dosage of 3 grams/65 kg of body weight daily seems to reduce blood alcohol levels by 35% to 51%.

Premature Ejaculation

Apply 0.20 grams of the SS-cream (which also contains many other herbs including cinnamon bark) to the glans penis 1 hour before sexual intercourse.

Selected References for Ginseng
Revised: December 15, 2009

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