(GSH) is an essential antioxidant that is needed to protect our body
against free radical damage.
know how important GSH is in protecting our tissues against reactive
oxygen species. However, it
is very unfortunate that this
supplement doesn't reach our blood when you take this in a pill form.
The cream and inhalation formulation are available and they
absorbed in the body. These are the forms we recommend you use.
effective way of getting glutathione into your system is by using an
Benefits and Traditional Uses
- Alzheimer's disease
- cancer prevention and treatment
- chronic fatigue syndrome (CFS)
- detoxification (detox) of the body
disease (cardiovascular disease)
- HIV Infection / AIDS
(high blood pressure)
- liver protection
- male infertility
- memory loss / dementia
- oral and pharyngeal cancer
- prevention of aging
- Parkinson's disease treatment
and Frequently Asked Questions (FAQ)
is glutathione (GSH)?
also known as GSH, is
a protein that is made up of three amino acids,
cysteine, glutamic acid and glycine.
is essential for repairing our DNA (genetic material), detoxification,
and the prevention damage to the cell (anti-oxidant benefits). It is an
essential free radical scavenger, effective at neutralizing oxygen
radicals and peroxides that can damage and kill cells.
studies in animals show that it is very helpful in helping our body get
ride of toxins such as poison, pesticides and heavy metals. Studies
done in the lab on cancer cells shows it can prevent against some forms
In our liver, it is used in the detoxification
process such as protection from toxins from cigarettes, alcohol and
overdose of certain medications.
What health conditions do this supplement
help treat or cure?
to jump to
the section on suggested benefits and traditional uses.
What health problems would cause low levels of
ailments seem to be linked to low levels of GSH. These include
, low sperm count or motility, HIV/AIDS,
cancer and cataracts.
As well, if you smoke, your body uses more GSH to fight off the toxins
found in tobacco smoke.
Does this supplement help with the skin?
supplement is used on the skin for cosmetic purposes. It can slow down
the production of melanin (a protein produced by melanocytes that gives
your skin the brown colour). In some countries, it is marketed as
bleaching cream or soap.
glutathione helps to treat or cure autism. Is that true?
clinical studies suggest that autism spectrum disorders (ASD) might
caused by too little glutathione present to protect the brain cells for
one study, children with autism shows "lowered glutathione reserve
capacity" and that this may "compromise antioxidant defense and
The researchers suggest that GSH supplementation might help children
suffering from autism.
Is there any
evidence that glutathione can help prevent cancer?
the amount of reactive oxygen species that may be a cause of
cancer cell growth. Experts strongly believe that the depletion of GSH
can be an important cause of some forms of cancer.
Studies will need to be done in animals and humans to prove that GSH
can prevent cancer.
Is there any
evidence that GSH helps with Parkinson's disease?
show that people with Parkinson's disease has lower levels
of GSH in the part of the brain involved in this disease. It is at
least 40 to 50% lower.
In one clinical study, patients treated with intravenous GSH showed
improvements in symptoms when they were given 600 mg twice daily for 30
days. The benefits lasted for 2 to 4 month after GSH was stopped.
The researchers suspect that low levels of GSH can speed up nerve cell
death in those people suffering from Parkinson's disease. They
believe it is because GSH has potent antioxidant
Does GSH help
with infertility in males?
Yes. A well
designed clinical study showed that intramuscular GSH injection at a
dose of 600 mg every other day for 2 months improved sperm motility
significantly. Other studies showed that GSH can increase sperm counts.
The researchers suggested that GSH injections could represent a
possible solution to treat certain types of infertility.
What foods contain glutathione?
Foods rich in
this supplement include fruits, walnuts, vegetables and fish
and meat sources.
I've heard that the pills do not get absorbed by
the body. Is that true?
it seems that the pill form doesn't get into our body. Taking high dose
of glutathione doesn't affect the blood level of this supplement. One
study in healthy volunteers used a 3,000 mg
dose and it has absolutely no effect on blood levels. Expert suspect
this supplement is destroyed by stomach acid and digestive enzymes in
Studies done in rats show that giving them this supplement in their
diet caused the blood levels to increase. However, this is because the
rat's intestine is missing an enzyme thus the glutathione is not
are experimenting with other formulations such as nose sprays,
injections, and oral dissolving tablets to see if these ways are able
to get the protein into our body. (This is the same reason why
insulin, also a
protein, needs to be injected by diabetic patients.)
What are some of the side effects of taking
there are very few reported side effects from taking this supplement.
There are also no known interactions with other herbs or prescription
to Take It
What dose is usually used in a pill form?
used ranges from 500 mg to 3,000 mg daily (divided to two or
three times daily). However studies show that even taking a
mg dose, it does not have any effect on blood levels.
For injections, what is the usual
intramuscular injected dose is 600 mg every other day for 2 months for
treating infertility in males. We advise using the injectable
formulation under the supervision of your family doctor.
For the nasal spray formulation, what is the dose?
In a nose
spray formulation, research studies used 600 mg twice
Is there a transdermal or patch formulation?
transdermal formulation can be purchased from many companies.
Pharmacies that compound can also make it up. There is no typical dose.
Concentration can be 10% to 20% in a penetrating cream or gel base (PLO
References for Glutathione
November 5, 2009