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Research Papers - Selected Studies

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Below is our list of selected research studies referenced. The main reference list is located in the page entitled References.


Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae. Yuan JP, et al.
Mol Nutr Food Res. 2011 Jan;55(1):150-65.

Modulatory effects of an algal extract containing astaxanthin on UVA-irradiated cells in culture. Lyons NM, O'Brien NM.
J Dermatol Sci. 2002 Oct;30(1):73-84.

Astaxanthin diminishes gap junctional intercellular communication in primary human fibroblasts. Daubrawa F, Sies H, Stahl W.
J Nutr. 2005 Nov;135(11):2507-11.

Haematococcus astaxanthin: applications for human health and nutrition. Guerin M, Huntley ME, Olaizola M.
Trends Biotechnol. 2003 May;21(5):210-6.

Effects of astaxanthin from Haematococcus pluvialis on human skin.
Seki et al., 2001.
Fragrance Journal 12:98-103

Cosmetic benefit of dietary supplements including astaxanthin and tocotrienol on human skin.
Yamashita, E.
2002, FOOD Style 21, 6:(6) 112-117.

Effect of a Dietary Supplement Containing Astaxanthin on Skin Condition.
Yamashita, E.
Carotenoid Science 2006. Vol. 10: 91-95.

Superior skin protection via Astaxanthin.
Arakane, Y.
Cartenoid Science, April 2002, Vol. 5

Astaxanthin attenuates the UVA-induced up-regulation of matrix-metalloproteinase-1 and skin fibroblast elastase in human dermal fibroblasts.
Suganuma K, et al.
J Dermatol Sci. 2010 May;58(2):136-42.

Modulation of UVA light-induced oxidative stress by beta-carotene, lutein and astaxanthin in cultured fibroblasts. O'Connor I, O'Brien N.
J Dermatol Sci. 1998 Mar;16(3):226-30.

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Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease.
Nakamura S, Hashimoto Y, Mikami M, Yamanaka E, Soma T, Hino M, Azuma A, Kudoh S.
Respirology. 2003 Sep;8(3):316-20.

Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars.
Al-Khateeb TH, Nusair Y.
Int J Oral Maxillofac Surg. 2008 Mar;37(3):264-8.

A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model.
Chopra D, Rehan HS, Mehra P, Kakkar AK.
Int J Oral Maxillofac Surg. 2009 Apr;38(4):350-5.

Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo.
Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G.
J Int Med Res. 1990 Sep-Oct;18(5):379-88.

Clinical study of the efficacy of and tolerance to seaprose S in inflammatory venous disease. Controlled study versus serratio-peptidase
Bracale G, Selvetella L.
Minerva Cardioangiol. 1996 Oct;44(10):515-24.

A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome.
Panagariya A, Sharma AK.
J Assoc Physicians India. 1999 Dec;47(12):1170-2.

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Saw Palmetto

Inhibition of Inflammatory Gene Expression in Keratinocytes Using a Composition Containing Carnitine, Thioctic Acid and Saw Palmetto Extract.
Chittur S, Parr B, Marcovici G.
Evid Based Complement Alternat Med. 2009 Aug 19.

A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia.
Prager N, Bickett K, French N, Marcovici G.
J Altern Complement Med. 2002 Apr;8(2):143-52.

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Curcumin's Effect on Intestinal Inflammation and Tumorigenesis in the Apc(Min/+) Mouse.
Murphy EA, Davis JM, McClellan JL, Gordon BT, Carmichael MD.
J Interferon Cytokine Res. 2010 Oct 15.

Potential of the dietary antioxidants resveratrol and curcumin in prevention and treatment of hematologic malignancies.
Kelkel M, Jacob C, Dicato M, Diederich M.
Molecules. 2010 Oct 12;15(10):7035-74.

Dietary polyphenolic phytochemicals--promising cancer chemopreventive agents in humans? A review of their clinical properties.
Thomasset SC, Berry DP, Garcea G, Marczylo T, Steward WP, Gescher AJ.
Int J Cancer. 2007 Feb 1;120(3):451-8.

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Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate.
Tamura H, et al.

J Pineal Res. 2008 Apr;44(3):280-7.

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Tea Tree Oil

The battle against multi-resistant strains: Renaissance of antimicrobial essential oils as a promising force to fight hospital-acquired infections.
Warnke PH, Becker ST, Podschun R, Sivananthan S, Springer IN, Russo PA, Wiltfang J, Fickenscher H, Sherry E.
J Craniomaxillofac Surg. 2009 Oct;37(7):392-7.

Successful topical treatment of hand warts in a paediatric patient with tea tree oil (Melaleuca alternifolia).
Millar BC, Moore JE.
Complement Ther Clin Pract. 2008 Nov;14(4):225-7.

The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study.
Enshaieh S, Jooya A, Siadat AH, Iraji F.
Indian J Dermatol Venereol Leprol. 2007 Jan-Feb;73(1):22-5.

Tea tree oil reduces histamine-induced skin inflammation.
Koh KJ, Pearce AL, Marshman G, Finlay-Jones JJ, Hart PH.
Br J Dermatol.  2002 Dec;147(6):1212-7.

Tea tree oil: a systematic review of randomized clinical trials.
Ernst E, Huntley A.
Forsch Komplementarmed Klass Naturheilkd. 2000 Feb;7(1):17-20.

Growth inhibition of pathogenic bacteria and some yeasts by selected essential oils and survival of L. monocytogenes and C. albicans in apple-carrot juice.
Irkin R, Korukluoglu M.
Foodborne Pathog Dis. 2009 Apr;6(3):387-94.

Antiviral activity of Australian tea tree oil and eucalyptus oil against herpes simplex virus in cell culture.
Schnitzler P, Schön K, Reichling J.
Pharmazie. 2001 Apr;56(4):343-7.

In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species.
Mondello F, De Bernardis F, Girolamo A, Cassone A, Salvatore G.
BMC Infect Dis. 2006 Nov 3;6:158.

The efficacy of Aloe vera, tea tree oil and saliva as first aid treatment for partial thickness burn injuries.
Cuttle L, Kempf M, Kravchuk O, George N, Liu PY, Chang HE, Mill J, Wang XQ, Kimble RM.
Burns.  2008 Dec;34(8):1176-82.

Acaricidal activity of Melaleuca alternifolia (tea tree) oil: in vitro sensitivity of sarcoptes scabiei var hominis to terpinen-4-ol.
Walton SF, McKinnon M, Pizzutto S, Dougall A, Williams E, Currie BJ.
Arch Dermatol. 2004 May;140(5):563-6.

Studies in vitro on the relative efficacy of current acaricides for Sarcoptes scabiei var. hominis.
Walton SF, Myerscough MR, Currie BJ.
Trans R Soc Trop Med Hyg. 2000 Jan-Feb;94(1):92-6.

A comparison of botanical and synthetic substances commonly used to prevent head lice (Pediculus humanus var. capitis) infestation.
Canyon DV, Speare R.
Int J Dermatol. 2007 Apr;46(4):422-6.

Development of a paw paw herbal shampoo for the removal of head lice.
McCage CM, Ward SM, Paling CA, Fisher DA, Flynn PJ, McLaughlin JL.
Phytomedicine. 2002 Dec;9(8):743-8.

Treatment of interdigital tinea pedis with 25% and 50% tea tree oil solution: a randomized, placebo-controlled, blinded study.
Satchell AC, Saurajen A, Bell C, Barnetson RS.
Australas J Dermatol. 2002 Aug;43(3):175-8.

Melaleuca alternifolia (tea tree) oil gel (6%) for the treatment of recurrent herpes labialis.
Carson CF, Ashton L, Dry L, Smith DW, Riley TV.
J Antimicrob Chemother. 2001 Sep;48(3):450-1.

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CoQ10 (Coenzyme Q10)

Kaneka Corporation study. Treadmill test with the aged rat at age of 61-63 weeks. 2006.

Yan J, Fujii K, et al. Exp Gerontol. 2006 Feb;41(2):130-40.

Hosoe K, Kitano M, et al. Regul Toxicol Pharmacol. 2006 Aug 17

Shults CW, Oakes D, Kieburtz K, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol. 2002 Oct;59(10):1541-50.

Hoppe U, Bergemann J, Diembeck W, et al. Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors. 1999;9(2-4):371-8.

Horowitz S. Coenzyme Q10: one antioxidant, many promising implications. Altern Comp Therapies. 2003 Jun:111-6.

Ghosal S. Shilajit in Perspective. New Delhi: Narosa Publishing House; 2006.

Pharmacology online. 2009;1:817-25.

J Strength Cond Res. 2009 Jul 28.

Life Extension Clinical Research, Inc.

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Ginger for Cancer

Growth Inhibition of Human Non-Small Lung Cancer Cells H460 By Green Tea and Ginger Polyphenols.
Hessien M, El-Gendy S, Donia T, Sikkena MA.
Anticancer Agents Med Chem. 2011 Oct 25.

Zingiber officinale Roscoe (ginger) as an adjuvant in cancer treatment: a review.
Pereira MM, Haniadka R, Chacko PP, Palatty PL, Baliga MS.
J BUON. 2011 Jul-Sep;16(3):414-24.

Phase II Study of the Effects of Ginger Root Extract on Eicosanoids in Colon Mucosa in People at Normal Risk for Colorectal Cancer.
Zick SM, Turgeon DK, Vareed SK, Ruffin MT, Litzinger AJ, Wright BD, Alrawi S, Normolle DP, Djuric Z, Brenner DE.
Cancer Prev Res (Phila). 2011 Nov;4(11):1929-37.

In vitro antioxidant and anticancer activity of young Zingiber officinale against human breast carcinoma cell lines.
Rahman S, Salehin F, Iqbal A.
BMC Complement Altern Med. 2011 Sep 20;11:76.

Administration of 6-gingerol greatly enhances the number of tumor-infiltrating lymphocytes in murine tumors.
Ju SA, Park SM, Lee YS, Bae JH, Yu R, An WG, Suh JH, Kim BS.
Int J Cancer. 2011 Jul 25. doi: 10.1002/ijc.26316.

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CoQ10 for Breast Cancer

Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated postmenopausal breast cancer women with special reference to blood chemistry profiles.
Yuvaraj S, Premkumar VG, Shanthi P, et al.
Breast Cancer Res Treat. 2009 Mar;114(2):377-84.

Exogenous coenzyme Q10 modulates MMP-2 activity in MCF-7 cell line as a breast cancer cellular model.
Bahar M, Khaghani S, Pasalar P, Paknejad M, et al.
Nutr J. 2010 Nov 30;9:62.

Anti-angiogenic potential of CoenzymeQ10, riboflavin and niacin in breast cancer patients undergoing tamoxifen therapy.
Premkumar VG, Yuvaraj S, Sathish S, et al.
Vascul Pharmacol. 2008 Apr-Jun;48(4-6):191-201.

Effect of coenzyme Q10, riboflavin and niacin on serum CEA and CA 15-3 levels in breast cancer patients undergoing tamoxifen therapy.
Premkumar VG, Yuvaraj S, Vijayasarathy K, et al.
P. Biol Pharm Bull. 2007 Feb;30(2):367-70.

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CoQ10 for Cancer

Coenzyme Q10 attenuated DMH-induced precancerous lesions in SD rats.
Kim JM, Park E.
J Nutr Sci Vitaminol (Tokyo). 2010;56(2):139-44.

Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3',4,4'-tetrachlorobiphenyl (PCB-77).
Tharappel JC, Lehmler HJ, Srinivasan C, et al.
Food Chem Toxicol. 2008 Nov;46(11):3467-74.

Coenzyme Q10 as a potent compound that inhibits Cdt1-geminin interaction.
Mizushina Y, Takeuchi T, Takakusagi Y, et al.
Biochim Biophys Acta. 2008 Feb;1780(2):203-13.

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